Two years into the COVID-19 pandemic, much still feels the same, though in some important ways our thinking and behaviors may be shifting in anticipation of longer-term changes in the ways we structure our lives and our shared places and spaces. In higher education, these shifts may reflect an evolution from short-term "emergency" or "reactive" modes of offering education during extraordinary circumstances to making strategic and sustainable investments in a future that will be very much unlike our past. As this year's teaching and learning Horizon panelists gathered to reflect on current trends and the future of higher education, many of their discussions and nominations suggest that change may be here to stay and that there will be no return to "normal" for many institutions. This report summarizes the results of those discussions and nominations and serves as one vantage point on where our future may be headed.